mutation story Biology Diagrams Many other mutations have no effect on the organism because they are repaired beforeprotein synthesis occurs. Cells have multiple repair mechanisms to fix mutations in DNA. It is generally caused by mutations in genes that regulate the cell cycle. Because of the mutations, cells with damaged DNA are allowed to divide without limits. This study is a cross-cancer type analysis of the effects of TP53 mutations on gene expression. A hierarchical cluster analysis of the expression profile of the p53 signaling pathway classified 21
Cancer-associated mutations that perturb cell cycle control allow continuous cell division chiefly by compromising the ability of cells to exit the cell cycle. recapitulates the effect of
4.10: Mutation Effects Biology Diagrams
Cancer is a systemic manifestation of aberrant cell cycle activity and dysregulated cell growth. Genetic mutations can determine tumor onset by either augmenting cell division rates or restraining normal controls such as cell cycle arrest or apoptosis. As a result, tumor cells not only undergo uncontrolled cell division but also become compromised in their ability to exit the cell cycle
The inhibitory effects on cell growth are consistent across different cancer types carrying diverse p53 mutations. Furthermore, CP-31398 has been shown to increase ROS production, triggering apoptosis in multiple myeloma cells regardless of p53 status ( 121 ).
7.4: Mutations and Cancer Biology Diagrams
The results indicated that the cancer types can be classified into two major groups based on the magnitude of gene expression changes related to the cell cycle and cell proliferative activity caused by TP53 mutations. Furthermore, there was no distinct difference in the effects of GOF and non-GOF mutations on the gene expression profile of the
